Persons may thus have type a, type b, type o, or type ab blood. Abo blood group systemabo blood group system the abo blood group system is the most important blood group system in human blood transfusion. Antigens are the proteins on the surface of red blood cells. Abo inheritance and genetics the abo gene is autosomal the gene is not on either sex chromosomes the abo gene locus is located on the chromosome 9. In 1900 karl landsteiner reported a series of tests, which identified the abo blood group system.
By the early 1920s, sufficient data were obtained to conclude that the mode of inheritance of the blood groups is compatible with the. Biochemistry, inheritance and biosynthesis of the abh and lewis antigens, 9. A family with examples of the rare condition known as inherited mosaicism affecting the abo blood groups has been studied. Table 62 gives information on the blood group systems other than the nine major systems. Abo blood group system, the classification of human blood based on the inherited properties of red blood cells erythrocytes as determined by.
Inheritance patterns of blood groups australian red. Simple inheritance of 3 gene options a, b or o giving four possible groups a, b, ab and. Genetic characterisation of human abo blood group variants with. Molecular genetic study of the histoblood group abo system has elucidated the allelic basis of this genetic locus. Both of these sugars are built upon the h antigenif the h antigen is left unmodified, the resulting blood group is o because neither. Blood group systems most blood group systems abo and others are made up of. Blood of one group contains antibodies in the plasma that. Note that h antigen is in a separate system, h blood group system 018, and is not part of the abo system. An antigen on a red cell and the absence of its corresponding antibody in the serum if youre a, you dont have antia if you do not have a particular antigen on your red cells then it is possible when exposed to foreign rbcs to illicit an immune response that results in the production of the. Molecular genetics of the abo histoablood group system. Blood caries many chemicals, which have various functions. The abo blood group system is determined by the abo gene, which is found on chromosome 9. Found on platelets, epithelium and cells other than erythrocytes, ab antigens can also cause an adverse immune response to organ transplantation.
One group of chemicals is called antigens, which can stimulate the production of antibodies. Inheritance and genetic of blood group linkedin slideshare. The abo blood group blood groups and red cell antigens ncbi. Based on the presence or absence of blood antigens and antibodies, four groups a, b, ab and o are recognized in human body. Biochemistry and genetics of the abo, lewis, and p blood group. In this content, the principle, history, method and facts of abo blood group system is explained. In human blood transfusions it is the most important of the 36 different blood type or group classification systems currently recognized. Blood groups are inherited from our parents in the same way as other genetic traits eg, eye colour. The abo blood group system is used to denote the presence of one, both, or neither of the a and b antigens on erythrocytes. Abo blood group system madison area technical college. Abo blood group system is one of the most popular method that classifies the blood give majorly into four types i. Paternity testing since the inheritance of the abo blood group system is very specific, this serves as one of the first methods to determine the likelihood that the accused father is the father or not.
A mismatch very rare in modern medicine in this, or any other serotype, can cause a potentially fatal adverse reaction after a. There are four common blood groups in the abo system. Experts thought that at last they had found genetic features that, because they are inherited and not susceptible. Blood group genespecified transferase estimations were studied. One copy is inherited from our mother, the other from our father. Abo blood group system, the classification of human blood based on the inherited properties of red blood cells erythrocytes as determined by the presence or absence of the antigens a and b, which are carried on the surface of the red cells. Abo blood group system abh oligosaccharide antigens, antia and antib, a and b glycosyltransferases, and abo genes find, read and. The four abo blood groups, a, b, ab and o, arise from. The discovery of the abo blood group, over 100 years ago, caused great. Inheritance of abo and rhd mother father group a ao group b bo rhd pos dd rhd pos ddgroup a ao group b bo group o oorhd pos dd rhd pos dd rhd neg dd 15 16.
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